Otto Octavius (voice) / Doctor Octopus (voice) / Master Planner (voice) / Otto Octavius / Doctor Octopus (voice) / Master Planner / Otto Octavius (voice) / Master Planner / Doctor Octopus (voice)

Professor Ivo (voice) / Professor Ivo / Amazo / M.O.N.Q.I. (voice) / Professor Ivo / M.O.N.Q.I. (voice)

Tom Lennox

The Invader (voice)

Jeff Kane

Stingo

Alan Birch

Larry Fleinhardt

Dr. Janosz Poha

Fenwick (voice)

Sedgwick

Major (voice)

Muru (voice)

Marty

Secretary of Defense

Egghead (voice)

Tire Repairman